Lack of patient’s awareness on the importance of adherence to drug regimen is implicated as one among the several factors affecting patient safety. The impact of non-compliance increases substantially in compromised conditions such as end stage renal diseases (ESRD). It is necessary to explore all possible steps to improve patient compliance. Thus, the current study was carried out to investigate the impact of counseling on provisions of quality of life (QOL) in patients with ESRD on hemodialysis.The data in the present research was obtained from the questionnaire-based study from 150 patients at four different hospitals with inclusion criteria of suffering from kidney failure, receiving dialysis and residents of Riyadh.Our study shows that the vast majority (88%) of the patient under hemodialysis in ESRD are receiving counseling from health care professionals. Most of the patients express their satisfaction for the services provided by health care team (88.7%) and also satisfied with their QOL (78.7%). Patient’s satisfactions were reflected by their daily activities, adherence to medications and enhanced awareness about negative impact of over the counter (OTC) medications. The outcome of the study is very encouraging as most of the patients express their satisfaction on the available counseling services and its impact on their QOL. However, there is a need for disseminating the counseling strategies among all patients in order to attain a widespread enhanced quality of life in patients with ESRD of Riyadh. This study cannot be generalized for the entire Kingdom of Saudi Arabia unless similar prevalence of counseling exists in other part of the Kingdom as seen in Riyadh