In this study, concentration of cross carmelose sodium (CCS), microcrystalline cellulose (MCC) and maltose have optimized in self-micro emulsified tablet (SMET) of cinnarizine (CNZN), a piperazine derivative antihistaminic drug. The self-micro emulsified liquids (SELS) of CNZN were prepared with Linoleic acid, PEG 400 and Tween 80. The SMET of SELS were prepared by adsorption followed by compression phenomenon using CCS (A), maltose (B) and MCC (C) which were optimized through 23 factorial design considering responses like disintegration time (DT), time for 50 % (t50) and time for 80% (t80) of drug release. Droplet size and turbidity of disintegrated SMET emulsion sample was within 2.58 ± 7.48 to 4.84 ± 5.83 µm and 16.47 ± 6.35 to 27.10 ± 6.12 nephlometric turbidity units (NTU) respectively. The factors A and B were directly and C was inversely related with responses. Response surface methodology was used to predict the levels of the factors A, B and C required for obtaining an optimum formulation with minimum dissolution time. Observed responses were in close agreement with the predicted values of the optimized formulation, thereby demonstrating the feasibility of the optimization procedure in developing self-micro-emulsified tablet dosage forms.