The main objective of the study was to evaluate the possible analgesic and central nervous system (CNS) depressant effects of methanol (MMPL), petroleum ether (PMPL), chloroform (CMPL), dichloromethane (DMPL) and aqueous (AMPL) extracts of the M. paniculata leaves. Analgesic effect was evaluated by acetic acid induced writhing and hot plate methods at 50 and 100 mg/kg dose. The CNS-depressant effect was assessed by using open field, hole cross and head deep tests at 100 and 200 mg/kg dose. All the extracts had exhibited significant (Pb < 0.01, Pa < 0.001) analgesic and CNS depressant effects at dose dependant manner. AMPL showed maximum analgesic effect with 72.92% inhibition of abdominal writhing and 33.03% maximal possible effect (MPE) of paw licking time at 100mg/kg dose. On the other hand, CMPL had shown highest CNS-depressant effect with 93.80% inhibition in open field, 84.63% inhibition in hole cross and 81.54% inhibition (head deeping) in head deep test at 200mg/kg dose. Among the five extracts AMPL is a potent analgesics and CMPL is a potent CNS-depressant agents. These findings may unveil the efficiency of these extracts as analgesics and CNS depressant drug which may lead to develop a new phyto-medicine