Alternative therapies for the alleviation of chemical/xenobiotic-induced metabolic aberrations and risk factors for cardiovascular disease have been inadequately explored, despite their rich cardiovascular protective bioactive constituents. The aim of the present study was to accurately evaluate the effect of Cymbopogon citratus extract on gasoline-induced oxidative stress, hyperglycaemia, hyperuricemia, dyslipidaemia, and atherogenic index of plasma (AIP) in rats. Seventy-two female Wistar albino rats were segregated into six groups (n = 12 per group). The rats in group 1 served as controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Rats in groups 3, 4, and 5 were exposed to GV and co-administered 500 mg/kg, 1000 mg/kg, and 1500 mg/kg C. citratus leaf extract, respectively, once daily for 14 days. Rats in group 6 were exposed to GV and co-administered 200 mg/kg vitamin C for the same time period. The results showed that group 2 had significantly higher glycaemic levels, lipid parameters (TG, T-chol, and LDL-C), uric acid (UA), MDA, and AIP and significantly lower (p < 0.05) HDL-C than group 1. Co-administration of C. citratus leaf extracts in groups 3, 4, and 5 and vitamin C to group 6 significantly lowered blood glucose levels, UA, lipid parameters MDA and AIP and simultaneously increased serum HDL-C in a dose-dependent manner. C. citratus leaf extract has an ameliorative effect against GV-induced oxidative stress, hyperglycaemia, hyperuricaemia, dyslipidaemia, and AIP, probably mediated through its varied bio – constituents and their activities