This study evaluated the analgesic property of Desmodium adscendens (DA) in mice using the Hot plate test and the Formalin test. Eighteen (18) mice of 15-25g body weight were used for this study. The mice were randomly assigned into 3 groups (control High dose (HD) and Low dose (LD) treated groups), n=6. Animals in the control group were given normal rat chow and water while animals in the test groups received different doses (100mg/kg and 400mg/kg) of D.A orally with the aid of an orogastric cannula alongside normal chow and water for 21days. At the end of the feeding period, nociception was evaluated following the hot plate and formalin test. The results showed that aqueous leaves extract of DA significantly (P<0.001) reduced the frequency and duration of paw lick but reduced escape latencies in the hot plate test compared with control. Frequency and duration of paw flick and paw attention in the acute phase of the formalin test was significantly increased (P<0.001) across the experimental groups compared with control. In the light of the above, low and high doses of DA were observed to reduce pain sensitivity following acute thermal pain stimuli whereas; it increases inflammatory pain sensitivity in mice. This indicates that D.A may be good analgesics of thermal cutaneous pain