Our study was carried out over 5 months from April 2014 to August 2014. Patients of uncomplicated cataract operated at tertiary care centre, Nanded by same surgeon with Manual small incision cataract surgery (SICS) with posterior chamber intra ocular lens (PCIOL) were studied. Objective is to find out co-relation between High IOP and topical 0.05% Difluprednate use on post-operative patients. Study Design was hospital based, prospective, observational Cohort study. Patients were started on topical antibiotic plus 0.05% difluprednate combination on first post-operative day and advised q.i.d. dosing. Then patients were followed for 6 weeks their IOP was measured by Goldmann Applanation Tonometer. Total of 56 eyes of either sex were included in the study. Our study showed that there is low risk of IOP rise in postoperative cataract patients i.e. 3.57% (2 out of 56 eyes) if schedule is followed. So our study concludes that strict following of dosing is necessary to get good outcome with difluprednate