The objective of this study was to evaluate the effects of two different mean arterial blood pressure (MAP) targets in septic shock. Sepsis is a syndrome is caused by a dysregulated inflammatory response to bacterial infections. We carried out a prospective observational study enrolling patients admitted to the ICU with sepsis from 01/01/2017to 01/03/2018. Both the medical and surgical units of the ICU were included. This study was conducted at Apollo Health City, Critical Care Medicine, Hyderabad, India after obtaining permission from the hospital ethics committee. A total of 100 members were included in this study, had septic shock. These were divided in to two groups aiming at increasing mean arterial pressure from 65mmHg to 80mmHg in older patients. MAP at the end of resuscitation was 57.32 ± 13.69 mmHg (mean ± SD) and 78.45 ± 17.23 mmHg respectively, for low-MAP and high-MAP groups. The high-MAP group had a more positive fluid balance. MAP below 65 mm Hg was shown to be associated with highest mortality during the first 48 hours of septic shock. The longer the time spent below MAP 65 mmHg, the higher the risk of mortality, acute kidney and myocardial injury. The MAP target of around 75–85 mmHg may reduce the incidence of acute kidney injury (AKI) in patients with chronic hypertension. The perfusion pressure is highly heterogenous not only between different patient but also in the same patient between different organs and different periods of septic shock. Hence the MAP target needs to be individualized according to patient requirements