Aim and Objectives: The aim of the study is to evaluate the effect of single visit apexification versus complete obturation with Mineral Trioxide Aggregate and Biodentine on the fractured resistance of simulated immature teeth. Material and Method: Forty five freshly extracted non-carious maxillary central incisors with single canal were selected. The apical 5mm of each tooth was then removed, access cavity preparation followed by preparation using peeso reamers was done to simulate Cvek’s stage 3 of root development. Irrigation protocol was carried out followed by randomization of samples and then canals were obturated using different materials. Fracture testing was done under universal testing machine and the ultimate load to fracture was recorded in Newtons. Statistical Analysis: Statistical analysis was done using SPSS 20.0 Software. One way analysis of variance followed by pair wise comparison of the groups was performed using Tukey’s post hoc test. The level of significance was set at 95% (p < 0.05). Results: All the experimental groups had a statistically higher value of fracture resistance than the control groups. Group I (entire canal obturated with MTA) showed highest value of fracture resistance followed by group III (entire canal obturated with biodentine), group II and group IV. Conclusion: Reinforcing immature teeth with bioactive materials such as MTA and biodentine is advantageous for apexification. Clinical Significance: Full MTA obturation clinically in patients might produce high success rate of apexification as compared to MTA and Biodentine apical plug and gutta percha obturation