It has been reported that there are effects of deep breathing and breath holding on the cardiovascular and blood pressure parameters. It is generally seen that BP tends to decrease during inhalation and increase during exhalation these changes may alter blood pressure measurements resulting in measured blood pressures being different. This study aims to find the effects of slow deep breathing practice on the blood pressure and Heart rate of young healthy adult male and female medical students. Methods: This study was conducted in the Department of Physiology, RVM Institute of Medical Sciences, Laxmakapally, Telangana. A total of n=50 subjects were selected randomly; the subjects were the medical students of RVM institute. Out of which (n=25) Group (M) males and (n=25) Group (F) were females. The baseline parameters of the subjects were recorded at the beginning of the study and the subjects were then trained for slow deep breathing @ 6 breaths per minute for a period of 3 months under the supervision of the investigator. Subjects are asked to take slow and maximal inspiration lasting for five seconds, followed by maximal expiration which also lasts for five seconds at a rate of 6 breaths per minute during each practice. A standard BP measurement was performed using a pneumatic cuff while listening to "Korotkoff sounds". All cardiovascular functional parameters were recorded before the trial, during breath-holding, and during recovery. Results: The values of SBP parameters in Group (M) Male before and after training were found to be significant. The DBP change in initial and final values in this group was not significant. The respiratory rates changes were also found to be significant in the Group (M). In the Group (F) no parameter was found to be changed significantly between the initial and final readings. The intergroup comparison of the parameters in the final readings shows a significant change in both SBP and DBP. Conclusion: it can be concluded that slow deep breathing for a period of 3 months decreases the blood pressure and heart rates and improves the autonomic functions. The effects are more marked in the male participants as compared to females of the same age group. The effect of slow deep breathing for long durations tends to improve the parasympathetic tone