A Pandemic of Influenza A (H1N1), caused by a new strain of the Virus started in Mexico in 2009. The first case in India was seen at Hyderabad in June 2009. Influenza A H1N1 2009 is transmitted by airborne droplet infection. The disease was initially known as Swine Flu, but now called as Seasonal Flu. The study has been carried out at M. P. Shah Government Medical College and Guru Gobind Singh Hospital, Jamnagar Gujarat. As per Ministry of Health and Family Welfare (MOHFW), Government of India guidelines, Category C Seasonal Flu patients were admitted in the Hospital. Out of 178 samples sent, 99 samples tested positive. 26 patients succumbed to the illness. Retrospective analysis of the Fatal cases were done with respect to various parameters. Maximum number of patients were in the age group above 60years. More number of fatal cases were in the age group of 40 to 49 years. Mortality was more in males although incidence was almost same in both sex. Presence of Co-Morbid illness was high amongst fatal cases. All fatal cases had low Oxygen saturation on presentation and were late in starting Oseltamivir after onset of symptoms. Even after 10 years Seasonal Influenza caused by H1N1 Virus carries significant mortality