Organophosphorus compounds are organic compounds containing phosphorus. They are used primarily in pest control as an alternative to chlorinated hydrocarbons that persist in the environment. Some organophosphorus compounds are highly effective insecticides, although some are extremely toxic to man, including sarin and VX nerve agents. To study the myocardial involvement in organophosphorus compound poisoning. Patients got admitted to the department of medicine, Adichunchanagiri institute of medical sciences, with history of organophosphorus compound poisoning during the period of January 2016 to December 2016. In the preset study, the incidence of OP compound poisoning common in males compared to females. Majority of patients were in the age group 31-49 years. The most common clinical finding in patients was tachycardia (36%) followed by bradycardia (32%). Hypertension was seen in 5 (20%) patients and 4 (16%) showed hypotension. Most common ECG finding was ST elevation (48%), Sinus tachycardia (24%) and QT prolongation (16%) and sinus bradycardia (12%). 15 (60%) of the patient had a significant levels of serum Acetylcholinesterase level >2500 IU/L. Cardiovascular effects are quite common following acute OP poisoning. These effects pertain to different muscarinic and nicotinic effects on the heart, electrolyte disturbances, ABG disorders, respiratory failure and over-atropinization.