Myrianthus aboreus is a medicinal plant that is widely distributed in Africa but common in Delta and Edo states of Nigeria. It is applied in folklore remedies in the treatment of some illnesses. This study was done to investigate the antidiabetic potential of the leaf of Myrianthus aboreus and it’s effects on some biochemical parameters of male wistar rats. The rats were divided into four (4) groups of five (5) rats each. Group one (1) which served as non diabetic control received normal saline only. Group 2 served as diabetic control and received normal saline after induction. Group three (3) and group four (4) were diabetic rats treated with 500mg/kg bw and 1000mg/kg bw of the hydromethanolic leaf extract of Myrianthus aboreus respectively, for a period of four (4) weeks. The results obtained showed that the higher dose extract caused a significant decrease in blood glucose level in week 4 of the study.The changes observed in the plasma concentrations of electrolytes, urea and creatinine were not statistically significant. This study showed that, the leaf extract of Myrianthus aboreus demonstrated hypoglycemic effects in alloxan induced diabetic wistar rats