Introduction: Since the introduction of H2 blockers and PPIs they have become one of the most commonly prescribed classes of medications in the world. These drugs are often misused and overused, which may have significant implications in the elderly. Aim: To study prevalence of irrational use of H2 blockers and PPIs in geriatric population. Methods: A retrospective study over six months period was conducted from February 2017 to Auguest2017 at a tertiary care hospital. The clinical data of total 137 patients admitted for one or more concurrent disease are included in the study. Results: In this study out of 137 patients, 102(74.4%) cases were on H2 receptors antagonist and 34(24.8%) were on PPIs which were irrationally prescribed. Mean age of the patients was 68.9 ±11.9 years. Out of 137 patients 103(75.1%) were male and 34(24.4%) female. Concurrent drugs prescribed were Antiplalets 19(13.8%) cases, CCBs 12(10.4%), ferrous sulphate13 (8.7%), steroids 10(7.2%), Digoxin 4(2.9%), Warfarin 2(1.4%), phenytoin 2 (2.9%). Conclusion: Irrational use of H2 receptor antagonists and PPIs in elderly increased with advanced age, increase in number of medications, multiple diagnoses and increased length of hospitalization. Effects and interactions were commonly encountered in many cases. Acid suppression drugs are initiated or continued for prolonged periods of time, without sufficient evaluation of the need for therapy. Proper Guidelines for physicians and counseling for the patients is required in order to reduce overuse and to prevent long term adverse effects of the drugs