A total of two hundred ears of CSOM cases in different age groups & sexes were subjected to bacteriological and clinical studies in the Department of Microbiology & ENT, Patna Medical College & Hospital. The ears were further subdivided into group I where ear swabs were studies for aerobic organisms and cultural & sensitivity pattern. In group II 50 swabs were studies for anaerobic organisms and culture and sensitivity pattern. The commonest organisms isolated in group I were Staphylococcus aureus followed by Pseudomonas aeruginosa while pepto-streptococci species were found in group II. Ciprofloxacin was found to be the drug of choice for most of the organisms followed by Norfloxacin,cefexime Cefoperazone & Gentamycin