Human monkeypox is a zoonotic orthopoxvirus disease with a presentation similar to the smallpox. The frequency and geographical spread of human monkeypox cases have increased recently in most countries of world. The disease is endemic in Democratic Republic of the Congo, Central and West Africa, but presently spread to other nations of the world including India that too when the whole world is facing the Covid -19 pandemic. In this article the author focus on the various parameters related to the monkeypox, present status and the stigmatization.