Background: Analyse the congenital malformations, involving various systems of the body systemwise & their association with maternal age and parity. Methods: This was a hospital-based cross-sectional study conducted at government maternity hospitals, Hyderabad over a period of one year months from October 2011 2015 to September 2012. All women attending Antenatal Clinic were screened by ultrasound examination. Foetuses of pregnant women were screened by clinical and ultrasonographic evaluation (12wks to 28wks). Results: The central nervous system and the musculoskeletal system topped the list with 16 cases (26.66%) out of total 60 cases. 11 cases of central nervous system belongs to 21-25 years age. Conclusion: Anomalies were most likely to be in the central nervous system. Maternal history of previous congenital anomalies, parental consanguinity, and history of medical disorders were associated with an increased risk of congenital anomalies. Early diagnosis will prevent mothers from psychological trauma of bearing and rearing an anomalous child.