Background: College students may experience severe sleep problems that negatively impact their health and well-being at certain times. The Partial sleep loss may increase the risk of obesity and weight gain. Aim: To assess the association between sleep quality and BMI in medical college students and to determine whether the students with poor sleep quality are at risk of developing obesity. Materials and Methods: 100 medical college undergraduate students of both the sexes aged between 18 - 25 years of Santhiram Medical College, Nandyal was included in the present study. Sleep quality was assessed by Pittsburg sleep quality index (PSQI) questionnaire. PQSI is a questionnaire based study, which is a standardized, quantitative measure of sleep quality with demonstrated high levels of consistency, reliability & validity. Body mass index (BMI) was calculated as weight (in Kg) divided by height-squared (in m2). The relationship between Body Mass Index (BMI) and sleep quality was analyzed in the present study. Results: Among 100 medical college students; 9 students were underweight, 45 were normal weight, 31 were overweight, and 15 were obese in the present study. The mean PSQI in underweight students was 3.1, normal weight was 3.4, and overweight was 2.67 and obese was 4.9.The mean BMI in students with PSQI<5 was23.04±3.89 and in those with PSQI >5 were 23.80±4.40. Conclusion: There was no association between sleep quality and BMI in the present study. We will extend our study in large sample size and by a different methodology with equal number of participants in each BMI category to determine better outcome in the present study.