Abstract: 2-[3’- Aminoacetyl amino-2’-methyl-6-monosubstituted quinazolin-4’(3’H)-onyl-imino]-4-thiazolidinones 5-6 were synthesised by cyclisation of 1-[3’-Aminoacetyl-2’-methyl-6’-monosubstituted quinazolin-4’(3’H)-onyl]-thiosemicarbazide 3-4 . 7-18 were synthesised by condensation of various substituted aldehydes at the 5th position of thiazolidinones 5-6. The newly synthesised compounds showed anticonvulsant activity ranging from 50%-90% (seizure protection). Compound 18, 2-[3’-aminoacetyl amino-2’-methyl-6’-bromosubstituted quinazolin-4’(3’)-onyl imino]-5-methyl-(p-N,N-dimethyl benzyl) -4-thiazolidinone showed maximum activity being more potent than the reference drug phenytoin sodium.