Electrolyte derangement is a common feature in anaemia. This study was undertaken to elucidate the effect(s) of ferrous sulphate on the renal handling of electrolytes. 28 male albino Wistar rats were randomly assigned to four groups of 7 rats each namely: the normal control given distilled water (10ml/kg body weight), ferrous sulphate administered ferrous sulphate (75mg/kg body weight), anaemic control given phenyl hydrazine (40mg/kg body weight) and the anaemic treated group given phenylhydrazine administered (40mg/kg body weight of phenyl hydrazine and 75mg/kg body weight) and ferrous sulphate. Results show that mean Na+ and Cl- levels in the serum (P<0.001) and urine (P<0.01 and P<0.001 respectively) of the anaemic control group was significantly higher than control and ferrous sulphate groups. K+ concentration in the serum of AC was significantly (P<0.001) higher than that of control and FES but significanlty (P<0.05) lower in urine of AC compared with control and FES. The bicarbonate concentration of the serum and urine of AC was significantly (P<0.05 and P<.001 respectively) lower than the FES group only. The levels of Na+, Cl-, K+ and HCO3- in the AFES group were not significantly different from any of the groups. Conclusion: We conclude that ferrous sulfate does not only restore Hb but also kidneys ability to handle electrolytes.