Background: Benign Prostate Hyperplasia (BPH) is an age associated prostate gland enlargement in men that can lead to urination difficulty. The exact etiology of BPH is unknown. However, inflammation is a critical factor in the development of BPH. Soursop as a traditional medicine has anti-inflammatory properties. This study investigated the anti-inflammatory potentials of soursop pulp extracts on induced benign prostatic hyperplasia (BPH) in adult male wistar rats. Materials and methods: Twenty-four adult male rats grouped into five were used for the study. BPH was induced subcutaneously in the inguinal region with testosterone propionate 3mg/kg/day. Acute toxicity test was carried out to determine the safety of the extract. The rats in group A served as the control group. Rats in group B, C and D were administered 200mg, 400mg, and 600mg of aqueous soursop extract per kg body weight/day. Biochemical analyses of the protein specific antigen, albumin, white blood cell count, testosterone, and C-reactive protein were performed after the trial. Statistical analysis was done using SPSS version 23. Results: Aqueous soursop pulp extract significantly decreased (p<0.05) the protein specific antigen by 58.87%. The extract at 400mg resulted in a percentage decrease in white blood cell count by 35.37% and albumin by 31.23 %. The extract at 600mg significantly decreased the testosterone and C- Reactive Protein by 59.88% and 69.47% respectively. Conclusion: The inflammatory bio-markers (prostate specific antigen, albumin, white blood cell count, testosterone, and C-reactive protein) studied after treatment revealed that aqueous soursop pulp extract is promising in the management of benign prostate hyperplasia.