Diabetes Mellitus type 2 is a group of disorders characterized by high glucose levels. Electrolyte abnormalities are commonly encountered in chronic diabetes mellitus type 2 patients. These patients usually have Potassium, Magnesium and Phosphate depletion. This study was conducted to investigate the electrolytes and lipid abnormalities in chronic type 2 diabetes mellitus in patients attending Rajiv Gandhi Institute of Medical Sciences and Hospital Adilabad. This study was conducted in the Department of General Medicine and Biochemistry, Rajiv Gandhi Institute of Medical Sciences [RIMS], Adilabad. The study included male and female subjects diagnosed with chronic diabetes mellitus type 2. Chronic diabetics were defined as those diagnosed with diabetes mellitus type 2 and on medications, for the duration of 5 years or more they were designated as Group I. Similarly age and sex-matched controls from the normal population were included in Group II as controls. Fasting blood samples will be collected in Vacutainer 10ml and serum fasting blood sugar, Serum Electrolytes and lipid profile will be estimated in fully automatic chemistry analyzer ‘Beckman Coulter Au 400’. The results obtained were recorded and analyzed using statistical software. Results: A total of 100 patients were included in the study divided into two groups Group I (diabetics) and group II (controls). The serum fasting blood glucose was measured in group I the mean values was 174.5 ± 25.6 mg/dl and in group II 96.5 ± 20.5 mg/dl the p values were found to be significant. The triglyceride levels as compared to controls the mean values in group I was 201.55 ± 35.8 mg/dl and group II was 190.5 ± 30.12 mg/dl the p values were found to be significant. The potassium levels were also elevated in the group I (diabetic) as compared to group II and the p values were found to be significant. It can be concluded that type 2 diabetes patients have abnormal lipid and electrolyte balance. The impaired mineral metabolism can result in disturbances in enzymatic activities, hormone secretions, and antioxidant levels. Therefore monitoring of these patients every 3 months will help in preventing the occurrence of long-term complications related to diabetes