The aim of the present study was to compare the efficacy of oral versus vaginal misoprostol in the induction of labor after 34 weeks of gestation to 40 weeks gestation and to find out any variation in the maternal and fetal outcome. Methods: This study was conducted in the Department of Obstetrics and Gynaecology at Prathima Institute of Medical Sciences, Karimnagar, and Telangana state for the period of one year. In the present study 100, antenatal women who are more than 34 weeks of gestation and who need induction of labor were selected for the study. To calculate the EDD, calculated using Naegele’s Formula. Women divided into Group A – 50 pregnant women, aged 18-32 years; with oral administration of 25 mcg Misoprost every 4th hourly, maximum of 6 doses (150mcg). Group B - 50 pregnant women, aged 18-32 years, with vaginal administration of 25mcg Misoprost every 4th hourly, maximum of doses of 6 doses(150mcg). In all the patients, the cervical status was assessed by using Bishop's score prior to induction. Repeat bishop's score was assessed at 4th hour and then before every repeat dose. Results: Parity a total of 57 women was primigravida while 43 were multigravida. For oral group 29 cases (58%) were primigravida, 21 cases (42%) were multigravida for the vaginal group, 28 cases (56%) were primigravida, 22 cases (44%) were multigravida. Augmentation with Oxytocin Of the total, 45% of the cases were on Oxytocin while remaining was not. For Oral Group 27 cases (54%) required augmentation with Oxytocin. Failed Induction In the study group, nearly 3% of the cases failed induction. In Oral group Failed induction incidence was in 3 cases (6%). In the Vaginal group, there was no failure of induction. 75% of the cases had a normal delivery, 12% showed vacuum delivery followed by C section (10%) and 3% cases had the forceps delivery.