Adverse Drug Reactions (ADRs) are scantly reported with poor contribution by healthcare professionals worldwide and in particular in developing countries. The aim of this study was to assess the knowledge and awareness of ADRs reporting and pharmacovigilance system among doctors and nurses in KLEs Tertiary care hospital Belagavi. A questionnaire was designed addressing; awareness of ADRs, knowledge of pharmacovigilance system, availability of ADRs reporting system. The questionnaire was distribute to doctors (n=160) and nurses (n=140) working in hospital. Completed questionnaires were collected, data were analyzed and data were expressed in number as well as percentage. Of the 300 questionnaires circulated, a total of 107 doctors and 107 nurses responded. The percent of the respondents who accepted to enroll in the study was 66.8% of doctors and 76.4% of nurses. Most of the respondents were unable to correctly define the pharmacovigilance term, but they were aware of ADRs. The awareness of the national pharmacovigilance system among doctors was 32.5% and nurses were 37.9%. (42.5%) doctors and (54.3%) nurses follow the reporting system to pharmagovigilance center. Our study has demonstrated a lack of knowledge and awareness of pharmacovigilance and ADRs reporting among healthcare professionals in hospitals. The poor knowledge of ADRs reporting emphasized the urgent need to implement the appropriate strategies to improve the awareness ofpharmacovigilance practices and ADRs reporting in our hospitals