A novel therapeutic use of Ethosuximide has come to light with the findings of powerful analgesic effects in experimental models as well as in humans.The analgesic effects of Ethosuximide were explored in various nociceptive models. Following intraperitoneal administration, ethosuximide dose-dependently reversed chemotherapy induced peripheral neuropathic pain and capsaicin-induced mechanical Allodynia, and produced antinociceptive effects in the rat-tail flick reflex test in male rats. Analgesia Produced by Ethosuximide is as good as that Produced by Gabapentin in Acute Pain models. Analgesia produced by extract of Ocimum sanctum is as good as that Produced by Ethosuximide, when compared with these drugs individually in acute pain models. In Neuropathic Pain induced by Ethosuximide Produces Significant Analgesia in Thermal Hyperalgesia Models and significantly reduces Cold Allodynia. The Ethosuximide in neuropathic pain relievers Thermal Hyperalgesia as well as cold Allodynia.