Smoking is a pernicious scourge of the world today. Smoking is well known to increase the risk of pulmonary and cardiovascular diseases by affecting the cardio–pulmonary functions. Hence, emphasis should be paid on preventive strategies of these disorders. Our study was to evaluate the effect of smoking on lung functions and lipid profile in asymptomatic smokers. A total of 100 male subjects were included which were equally divided in to two groups i.e. of smokers and non – smokers. The lung function tests and lipid profile was carried out on each subject in both the groups. No statistically significant difference was seen in the baseline characteristics of the two groups. There was no statistically significant difference between the two groups regarding mean values of blood pressure and heart rate, though; values were higher in smokers as compared to non-smokers. All the spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. No statistically significant difference was seen in the mean HDL – cholestrerol values in the two groups. Although the smokers were young and asymptomatic, still the spirometric and lipid values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All spirometric and lipid parameters deteriorated significantly with increasing pack years of smoking