Viral gastroenteritis is one of the most frequently occurring medical illnesses all over the world, especially in developing countries. Although, clinical features of viral gastroenteritis are generally limited to the intestine, they may also extend beyond the gastrointestinal tract, which could be life threatening and fatal. The etiology of viral gastroenteritis in adults usually remains unclear. The aim was to investigate the etiology and clinical profile among adult patients with acute viral gastroenteritis. Patients (100) underwent investigations including, hemoglobin test, urine examination, fasting blood sugar, liver function test, renal function test, and serum electrolytes. Stool specimens were tested for rotavirus and adenovirus using the rapid kit test. The categorical and continuous data were compared using chi-square test and student t-test, respectively. At 95% confidence interval, p ≤ 0.05 was considered as statistically significant. Of the 100 gastroenteritis patients, 26 patients were diagnosed positive for viral gastroenteritis. The leading cause of viral gastroenteritis was rotavirus (22) followed by adenovirus (4) and rotavirus-adenovirus co-infection (2). Diarrhea (100) was the major clinical feature. Incidence of gastroenteritis was mainly observed in patients (41) below 30 years of age. Acute viral gastroenteritis was significantly associated with the clinical features including vomiting, fever, dehydration, and reduced urine output; and biochemical parameters including renal and hepatic function abnormalities (p < 0.001). The study concluded that rotavirus, followed by adenovirus, can cause severe gastroenteritis and is an important etiologic agent in hospitalized adult cases of gastroenteritis.