Salt consumption is essential but has a negative health impact when taken in excess. Therefore, this research is aimed at investigating the possible role of Moringa oleifera leave extract on lipids and antioxidant enzymes following salt loading. 24 male albino Wistar rats weighing between 180-240g were used for this study and were divided into four groups (n=6). They were given either normal rat feed and drinking water, high salt diet (8% NaCl diet) + 1% NaCl drinking water and/or Moringa oleifera extract (600 mg/kg b.w., orally, once daily). After six weeks of feeding, the animals were sacrificed and blood collected through standard method for analysis. The salt fed untreated rats had significant (p<0.05) increase in Triglycerides (TG) level, Atherogenic indices (P<0.05), Malondialdehyde (MDA), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) (P<0.01). These parameters were significantly (p<0.05) reduced to near control values following extract treatment. Salt fed untreated rats were also observed to have significant (P<0.05) reduction in High density lipoprotein (HDL), Catalase (CAT) (P<0.01), Glutathione peroxidase (GPx) (P<0.05), Superoxide dismutase (SOD) and Albumin (ALB) (P<0.01), but the reverse was the case following extract treatment. In conclusion, consumption of Moringa oleifera leaf extract ameliorates the adverse effects of salt loading on the atherogenic, antioxidants and other indices thereby preventing possible outcome of cardiovascular disease, atherosclerosis and other related ailment. It is therefore being recommended for further research and possible use in the manufacture of drugs that are necessary in management of cardiac and other related ailments.