Introduction: The solitary rectal ulcer syndrome (SRUS) is a rare disorder of the rectal wall and its course is chronic but always benign. The therapeutic management of SRUS remains a challenge and relies on a multidisciplinary management. The objective of our study is to describe the epidemiological, clinical, therapeutic and evolutionary characteristics of SRUS in a Moroccan series. Materials and Methods: This is a monocentric descriptive retrospective study including all patients with SRUS in the Department of Hepato-Gastro-Enterology and Proctology "Médicine B" of the Ibn Sina University Hospital, over a period from January 2000 to August 2021. Results: A total of 26 patients were included with a mean age of 45 years [15-70 years] and a sex ratio (M/F) of 0.6. The most frequent clinical symptomatology was rectal bleeding found in all patients (100%), followed by anorectal pain (84.6%), bloody mucus evacuations (73.1%), chronic constipation (38.5%) and rectal prolapse in 34.6% of the patients at the proctologic examination. The low endoscopic exploration had detected mainly a single ulceration with clean bottom (50%), multiple ulcerations (20%) and a pseudo-polypoid aspect (15.4%). Histological examination of the biopsies taken from the ulceration and the periphery confirmed the diagnosis by showing the typical histological aspect of SRUS. The majority of our patients (77%) underwent anorectal manometry, which revealed anorectal dyssynergia and sphincter tone abnormalities. The therapeutic management was based on medical treatment in all patients, defecation rehabilitation "biofeedback" (53.8%) and surgical approach was considered in 19.2% of cases. Conclusion: The SRUS is an entity defined by its endoscopic and histological aspect, manifesting itself mainly by rectal bleeding. Recto-sigmoidoscopy and histology are the key to diagnosis. Treatment is primarily medical. Surgical treatment is indicated in case of failure of medical treatment or in case of occurrence of complications.