Background: Use of several anesthetic agents to induce anesthesia is not new and they are used to achieve different effects such as sedation, muscle relaxation and pain relief. Propofol has been accepted as an alternative to thiopentone for intravenous induction and is commonly used as an inducing agent and its action is more rapid. Objective: To compare co-induction with a small dose of ketamine is a better option compared to midazolam in reducing induction dose of propofol. Methods: This was a prospective, randomized, double-blind and interventional study conducted at Department of Anaesthesia, Institute of Child and Mother Health (ICMH), Matuail, Dhaka, Bangladesh from January to December-2019. Fifty two adult patients undergoing elective surgery to be performed under general anesthesia were randomized to receive 0.3 mg/kg of Ketamine or 0.03 mg/ kg of Midazolam intravenously as co-induction agent. A minute after administration of co-induction agent, anesthesia was induced with Propofol 40 mg bolus then 10 mg every 10 seconds until the loss of verbal response. The hemodynamic response at 0, 1, 2, 5 minutes respectively and the induction dose of Propofol were noted. Results: A total of 52 patients (n=26 in each group) who met the inclusion criteria were included in this study. The patients where between age group of 20 years to 71 years and weight of 40 kg to 80 kg and had ASA physical status 1. As there were no significant differences in age, sex, weight and ASA physical status of patients, between the two groups, both of the groups were comparable. The mean arterial pressure heart rates were significantly lower at 1, 2 and 5 minutes in midazolam group. However, mean arterial pressure and heart were within the physiological range in both the groups. Propofol dose requirement for induction between the two groups was similar (p>0.05) but co-induction significantly decreased the induction dose of Propofol as compared to standard recommended dose for induction. Conclusion: Our study showed that hemodynamic variables were maintained within the physiological range with midazolam and ketamine co-induction. However, lesser degree of decrease in mean arterial pressure was seen with ketamine but the heart rate was higher. A similar reduction of induction dose of propofol was achieved with both the drugs.