The sudden outburst of the pandemic COVID-19, in 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), had caught all by surprise, affected the entire world, and took the lives of many. This led to a desperate need for vaccines and India was one of the 11 countries that went ahead for the discovery of vaccines with manufacturing and export of the same. The first phase of vaccination was directed towards the frontline workers, including dentists, as they were at high risk. As vaccines have faced challenges in acceptability, there is a need to create awareness. The objectives are 1. Assess post-vaccination side-effects among dental professionals after both doses. 2. Assess any particular oral manifestations that can occur post-vaccination. The COVID vaccine was administered to all the healthcare workers of a private Dental College, Mysuru. The first dose was given in January, 28 days later the second dose was given. A questionnaire was developed and sent by email to be filled by those who were vaccinated to record and assess their experiences post-vaccination. A total of 141 responses were acquired and subjected to statistical analysis to evaluate their experiences and challenges. SPSS 22 was used for statistical analysis. The frequency, mean and mode were calculated of the acquired responses. We can conclude that in the absence of any co-morbidity and good immunity, the effects post-vaccination is mild, which can be subsided by taking appropriate symptomatic medications.