Anatomical illustrations have gradual changed since their inception. The pioneers of the field have initially used pencil drawings, followed by line illustrations, colored illustrations, two dimensional and three-dimensional illustrations, and it grew up to virtual reality. Recent studies have observed their benefit in teaching anatomy, especially for providing spatial orientation of various structures and complex topics such as middle ear, pterygopalatine fossa, where dissection cannot offer much comprehension. Drawing software such as Illustrator and Photoshop have revolutionized the image quality in anatomy textbooks. Adobe Illustrator comprises many useful tools to draw anatomical diagrams such as pen tool, pencil tool, paint brush tool, text tool. It has various paper sizes to choose and different formats of files to create vector-based images. The drawing hardware such as Wacom Cintiq, Apple iPad Pro with pencil enhances the experience with drawing software.