The diagnosis of cystic echinococcosis (CE) is based on imaging, but it is recommended to use serological test to support imaging in inconclusive cases. We performed a retrospective analysis of serology results of patients with CE lesions, seen from January 2016 to March 2020, to evaluate the contribution of the serology in the diagnosis accuracy and sensitivity of CE. Sera from eligible patients, including 86 patients with probable CE lesion, were used, with 2 commercial seroassays (NovaLisaTM Echinococcus IgG; NovaTec Immunodiagnostica, Germany and Western Blot; ECHINOCOCCUS Western Blot (WB) IgG from LDBIO diagnostics). Sensitivity of seroassays to liver cyst wasn’t significantly higher than lung cyst, but a statically significant correlation has been found between positive CE serology and complicated cysts (82% versus 55% p<0.001). Sensitivity and diagnostic accuracy of ELISA test combined to Western blot (WB) were higher than those obtained with ELISA test alone (65% versus 82% p= 0,001). Combining a first level seroassays as ELISA test with a high specific test as WB provide the best diagnosis accuracy for CE.