Solanum nigrum is one of the commonly found herb around the globe and contains diverse therapeutic along with biological control based potentials. For last few decades, not only aqueous but also other organic solvents based extract have been prepared to obtain maximum benefits of its components to recover external and internal wounds, inflammations, infections, cancer and to control many disorders like cytotoxicity, cardiovascular, hepatic, gastric and enzymatic complications. Moreover, it has been found as effective to reducer aging and an ideal local cost source of phytoremediation. For future progress, its dose and shots optimization should be focused by researchers.