Atherosclerotic heart disease due to the accumulation of large amount of lipids present in the blood vessels of arteries. Many animal models have been developed to study atherosclerosis, and allow for careful control of experimental conditions, food and environmental risk factors. Experimental animal models of atherosclerosis have become a valuable tool for providing information on the etiology, pathophysiology, and the mechanism of action of various drugs and compounds used in the treatment and complications of the disease. Compared to human models, the animal model is more easily manageable, as the combined effects of dietary and environmental factors can be controlled. Different models have their own advantages and disadvantages.