Cryptococcosis is a frequent and severe opportunistic mycosis caused by encapsulated yeast of the genus Cryptococcus. It is common in immunocompromised patients, particularly those infected with the human immunodeficiency virus. We report in our work a case of cryptococcemia in a patient with covid-19 under anti-inflammatory treatment. The diagnosis was based on the presence of encapsulated yeasts with Indian ink and positive culture on Sabouraud medium without cycloheximide with identification of Cryptococcus neoformans as the causative agent. The patient's outcome was fatal.