Combretum micranthum (CM) is well known for its ethno-medicinal uses in the northwest of Nigeria with little or no scientific basis. Thus, the aim of this research is to evaluate the methanol leaf extract fractions of Combretum micranthum for possible antioxidant compounds. The results of DPPH free radical scavenging showed that ethyl acetate fraction has a higher radical scavenging activity then followed by aqueous fraction of 87.913±3.927 and 84.718±0.605 respectively, compared with ascorbic acid reference standard 80.351±0.732 at 2500ug/m1 concentration. In FRAP, the result showed that ethyl acetate has a higher antioxidant property of 0.818±0.035 followed by aqueous which is 0.800± 0.002 compared to ascorbic acid which is 0.426±0.000. The LC-MS profile revealed the presences of several compounds as follows: 3,4,5-trihydroxy-6-(3-hydroxy-2-(2-hydroxypropan-2-yl)-7-oxo- 2H, 3H, 7H- furo (3,2-g) chromen -9-yl)oxy)oxane-2-carboxylic acid and (5- (1E) -3- (6- (3,4- dihydroxy -2,5- bis (hydroxymethyl) oxolan -2-yl) oxy) -3,4,5- trihydroxyoxan -2-yl) methoxy) -3- oxoprop -1- en -1- yl) -2-hydroxyphenyl) oxidane sulfonic acid in ethyl acetate fraction and Atavaquone, Fenarimol, 12-tricosanol, Myricetin, Histidylasparagine and Homocycteine thiolactone in aqueous fraction. The result of the docking revealed some potential and antioxidant activities of the fractions with significant binding interactions between compounds and alpha amylase & alpha glucosidase. Therefore based on the compounds identified by LCMS analysis coupled to the in-vitro antioxidant studies it can be concluded that these fractions of Combretum micranthum can be used against free radicals and potential in drug management.