This study investigated the histological and biochemical effects of G. kola and T.conophorum extracts, in diabetic Wistar rats. Phytochemical and LD50 of the extracts were determined. Thirty-six (36) adult male Wistar rats weighing 180 – 200 g were divided into 6 groups (n =6). Group 1 served as normal control, group 2 served as diabetic control while groups 3 – 6 were diabetic rats treated with glibenclamide (5 mg/kg body weight (bw)), G. kola (548 mg/kg bw), T. conophorum (524 mg/kg bw) and combined (G. kola and T. conophorum) respectively. At the end of the experiment, the animals were anaesthesized and with cardiac puncture, blood was obtained for biochemical studies while the kidneys were harvested for the histological analysis. Glibenclamide significantly (p < 0.05) reduced FBG from 22.10 ± 1.65 mmol/L to 4.48 ± 0.29 mmol/L, G. kola from 22.04 ± 4.06 mmol/L to 7.40 ± 2.41 mmol/L, T. conophorum from 14.26 ± 2.38 mmol/L to 5.98 ± 0.57 mmol/L, and combined from 17.54 ± 1.72 mmol/L to 11.58 ± 2.11 mmol/L. G. kola significantly (p < 0.05) lowered the urea and raised the chloride and creatinine levels. T. conophorum significantly (p < 0.05) reduced the urea and increased the sodium and chloride levels, while the combined treatment significantly lowered the urea and raised the sodium levels. The plant extracts significantly attenuated the alterations in the kidneys. It may be concluded that the combined administration of G. kola and T. conophorum extracts and their single treatments showed hypoglycaemic and nephroprotective effects.