Abstract: Sepsis is a clinical syndrome that complicates severe infection and is characterized by inflammation and widespread tissue injury. The clinical process usually begins with infection, which potentially leads to sepsis and organ dysfunction [1]. It is estimated that puerperal sepsis causes at least 75,000 maternal deaths every year, mostly in low-income countries [2]. To assess specific management of maternal sepsis in High Dependency unit (HDU) and its impact on maternal outcome. Prospective study carried out at HDU in Gauhati Medical College (GMCH) and Hospital from 1st June 2017- 30th July 2018.All patients with sepsis admitted to HDU during the period of study were studied for their response to management and outcome is evaluated. Out 74 patients with sepsis admitted to HDU, 42 expired due to severe sepsis, septic shock or MODS. The total number of maternal deaths during the study period was 148 due to various causes and the total number of live births was 15802. So maternal sepsis was responsible for 28 % of maternal deaths. The calculated MMR for the period of study was 936/ lakh live births and calculated MMR for maternal sepsis was 265 / lakh live births. From this study it can be concluded that sepsis is an important cause of maternal morbidity and mortality. A positive blood culture and the antibiotic susceptibility testing of the isolates are the best guide in choosing the appropriate antimicrobial therapy in treating sepsis. Blood and blood products, vasopressors also plays important role as adjunctive treatment of sepsis.