Background: Coronary artery disease is a progressively worsening condition that may present as stable angina or Acute coronary syndrome (Unstable angina/Non-STEMI or STEMI) when restriction of blood flow to the myocardium occurs. The present study is undertaken to determine the time taken in conversion of stable angina to acute coronary syndrome and to compare the incidence of ACS in male and female populations. Objective: To study the time taken in conversion of stable angina to Acute coronary syndrome in patients with coronary artery disease and to compare the incidence of ACS in the male and female population. Material and Methods: The present cross-sectional study was conducted at the cardiac ward and follow-up in the out-patient unit, Andhra Medical College, Visakhapatnam. 50 participants, male and female, admitted with ACS were taken for study after obtaining written informed consent by purposive sampling. Data is analyzed using SPSS 20.0. The statistical test used is the student’s t-test. Results: Out of the total population under study, 54% presented for the first time to the cardiologist with ACS only, 36% patients developed ACS from stable angina within a time interval of (0-6months) and 10% of patients developed it in the time duration of (>6months). While the incidence of STEMI is significantly higher in females than males (p=0.035), the incidence of non-STEMI is significantly higher in males than females (p=0.035). Conclusion: The present study indicates that the majority of the patients present with ACS as a diagnosis at their first visit to a cardiologist whereas stable angina gets converted to ACS in 6 months in most of the untreated patients. We recommend further detailed multicenter study in this area with a higher sample size to confirm the results and use them for benefit of society.