The human eye is an organ that can provide physicians with valuable clues for the recognition and management of many systemic diseases, including many disorders of the endocrine system. Ocular manifestations are common in many endocrine disorders such as diabetes mellitus and Graves' disease. However, there are a significant number of lesser-known endocrine diseases in which ocular changes are common. Endocrine glands communicate with each other through hormones. Hormones include cortisol, thyroid hormones, insulin, testosterone, estrogen and many others. They are made and stored in the endocrine glands and released by these glands to exert their effects on nearby or distant target organs. The main glands of the endocrine system are the hypothalamus, pituitary gland, adrenal glands, gonads (testes and ovaries), thyroid gland, parathyroid glands, and pancreas. Endocrine glands control the physiology of the human body and maintain its homeostasis. The effects of hyper or hyposecretion of each endocrine gland separately, usually manifest themselves in a multi-organ fashion. Some disorders of the endocrine system manifest in the eye first through a variety of distinct pathophysiological factors. It is an interdisciplinary pathology, falling under both endocrinology and ophthalmology, and knowing these ophthalmic manifestations is the most important step for the early detection, prevention, diagnosis, treatment and monitoring of these manifestations, which can thus significantly reduce the morbidity related to these disorders including permanent visual dysfunction.