The Silver Catfish Chrysichthys nigrodigitatus from the hydrosystem Lake Togo-Lagoon of Aného contributes to the socio-economic well-being and food security of local populations. However, this ecosystem is known to be threatened by trace elements contamination. This study aims to assess the human health risk associated with exposure to trace elements via the consumption of Silver Catfish. The study method followed four main steps as described by USEPA after measuring trace element concentrations in C. nigrodigitatus tissues. The results showed that some values greater than 1 were obtained in the dry season, for As in adults (THQ = 1.17) and children (THQ = 1.80) and for Cr in children (THQ = 1.11) and in the rainy season for As in children (THQ = 1.36). Regarding the consumption of whole fish organs analyzed, the THQ recorded in the dry season for Cd, Pb, Cr and As in adults and children and for Hg in children are all greater than 1. In addition, in the rainy season, the THQ obtained for Cd and As in adults and Cd, Pb, Cr, Hg and As in children, are also greater than 1. The total target hazard quotient (TTHQ) are all greater than 1 for muscles and for all the combined fish organs studied. The CR values of Cr and As obtained in the muscles and the combined fish organs are all unacceptable (CR > 10-4) in both adults and children during both seasons. Children are more exposed than adults and the consumption of all the organs studied is found to be more dangerous than muscles alone. Therefore, the consumption of vital fish organs such as gills, kidneys and liver should be avoided since they are the favorite sites for most pollutant concentration.