Microbes playing important role in progression of infectious diseases. Bacterial attack on the nervous and respiratory cells undergoes metabolic pool. Different types of fungi also causing the infections once the attack on the human body. These pathogenic fungi are Blastomyces dermatitidis and Histoplasma capsulatum sense an increase in temperature. Gut microbiome also playing important roles in the brain function and behavior by causing the several neurological disorders. These symptoms can be seen in epilepsy and in response to seizure interventions. Different amino acids have been used as a source of bacterial nutrition for example, tryptophan as one of the essential amino acid playing important role in catalyzing the different reactions in body. Riboswitches are the regulatory sequences that can bind to the active target molecules in order to regulate the gene expression of most of gens causing the abnormal response. Chloramphenicol is the drug that is used to control the infections caused by bacteria as it the broad spectrum antibiotic and can target broad range of bacterial strains.