The present study was aimed to evaluate the antibacterial and antioxidant properties of Acmella caulirhiza. The plant was harvested, identified, dried and pulverized. Five extractions were carried out: one by decoction and four by maceration with distilled water, ethanol/water mixture (70/30, v/v), methanol, and 95° ethanol as solvents. Phytochemical screening of A. caulirhiza extracts was performed according to the Sofowora method. The determination of the minimum inhibitory concentrations by the microdilution method in a liquid medium, allowed the evaluation of the antibacterial activity on Pseudomonas aeruginosa NR 48982, Staphylococcus aureus ATCC 43300, methicillin-resistant Staphylococcus aureus ATCC 33591, Klebsiella pneumonia NR 41897. Antioxidant activity was performed by DPPH radical scavenging and Fe3+ reduction tests. All A. caulirhiza extracts contained phenolic compounds (flavonoids, tannins, coumarins), mucilages, and resins. However, alkaloids, saponosides, cardiac glycosides, and anthocyanins were absent. They showed antibacterial activity with minimum inhibitory concentration values ranging from 8 to 32 mg/mL). The antioxidant activity of the DPPH extracts had concentrations (IC50) ranging from 0.098 ± 0.011 to 3.9040 ± 0.319 mg/mL. The Fe3+ ion reducing activities of the extracts ranged from 53.120 ± 0.443 to 22.267 ± 1.006 µg/mL. The extracts of Acmella caulirhiza contain secondary metabolites that can justify the antibacterial and antioxidant activities. The use of this plant in traditional medicine in the management of infectious pathologies could be justified.