SARS-CoV-2 is spread by the micro droplets from the infected people or by the contact with the polluted fomites. The coronavirus infects the alveolar and bronchial epithelium cells and travels to the tiny air sacs and to alveoli. Monotonous laboratory-biomarkers can give the complete record of health position of a patient in severe medical situations. ACE2 serves as a regulator of renin angiotensin aldosterone systems, which regulates the blood volume, blood pressure, and balance of electrolytes in the body, in addition to acting as a crucial SARS-CoV and SARS-CoV-2 receptor. Transaminases and lactate dehydrogenase (LDH) are nonspecific indicators of cellular inflammation and damage in COVID-19 patients. Biological materials from COVID-19 individuals have been used in various gene expression analysis, as well as those involving proteomic methods. Imaging biomarkers, which also include the magnetic resonance, positron emission tomography, and computed tomography, are categorized into the several groups according to their activities and properties. High neutrophil count, lymphopenia and leukocytes are the simpler preliminary constraints which directly differentiate between the severe and non-severe coronavirus victims.