One of the approaches towards alleviation of peptic ulcer disease is by use of antiulcer agents. Cost factor has an important role to play in the choice of antiulcer agents in ulcer therapy. Piper guineense, a flora to tropical Africa, is claimed by traditional medicine as a remedy for peptic ulcer. Despite its wide usage in crude form, purified form of Piper guineense are yet to be explored. The aim of the study was to evaluate the gastroprotective activities of fraction extracts of Piper guineense on ethanol-induced ulcer in wistar rats. This was done by administering orally, 400mg/kg of various fraction extracts to six test groups, 100mg/kg cimetidine to a positive control group and 5ml/kg Tween 80 (3% v/v) to a negative control group. Histological study and effect of the extracts on stomach weight were conducted. Findings revealed that extracts significantly (p<0.05) inhibited gastric ulceration with PF-4 producing 49.02% ulcer inhibition while cimetidine produced 81.93%. Histological study revealed gastroprotection with minor epithelial loss in extract-treated group. The extracts (PF-2, PF-4. EE) respectively produced 23.47%, 27.23% and 33.33% significant (p<0.05) increase in stomach weight of rats. In conclusion, the fraction extracts of Piper guineense possess gastroprotective activities.