Background: Obesity affects life span of an individual by increasing morbidity and mortality. Obese individuals usually affected by lipid abnormalities which serve as risk factors for complications like cardiovascular disease, hypertension, diabetes mellitus etc. The study aimed to evaluate lipid profile and blood pressure in obese and non-obese. Materials and Methods: Study was carried out at Department of Medicine, GG Hospital, Jamnagar over a period of one year. Total 105 subjects were enrolled in this cross sectional study after informed consent. Body Mass Index (BMI) and blood pressure were recorded by standard protocol. Based on BMI, subjects were divided into three groups: Group I - Normal weight (18.5 to 24.9 kg/m2) , Group II - Overweight (25 to 29.9 kg/m2) Group III - Obese (more than 30 kg/m2). Overnight fasting blood samples were collected and were analyzed for parameters like serum cholesterol, serum triglycerides, serum HDL, serum LDL & serum VLDL. Results: Blood pressure was elevated in Gr-III as compared to Gr-I+II (p<0.001). Serum Cholesterol, triglycerides, LDL, VLDL were elevated in Gr-III as compared to Gr-I+II (p<0.001). HDL was decreased in Gr-III compared Gr-I+II (P<0.001). Conclusion: Obese subjects showed lipid abnormalities like elevated Cholesterol, triglycerides, LDL, VLDL levels and decreased HDL level. Elevated blood pressure is also associated with Obesity.