In the beyond few years, there was a number of interests in and use of particulate delivery structures as immune providers each for small and large molecules withinside the area of drug administration. A form of drug molecule has pharmacokinetic and pharmacodynamic properties that adjust and enhance used inclusive of nanoparticles. In vivo, they were used to protect drug entities withinside the systemic circulation, restrict drug gets entry to sure areas, and distribute drugs at a regulated and constant price to the activity site. Various polymers are applied withinside the appearance of nanoparticles for drug delivery evaluation to increase healing benefit while decreasing side effects. This paper discusses an extensive variety of subjects associated with nanoparticle formulation, characterization, structural effects, and applications in drug delivery and therapeutic gene delivery. This study examines several themes relating to the formation of nanoparticles, characterisation, architectural impacts, and drug delivery and medicinal gene therapy application.