A Coronavirus disease 2019 (COVID-19) is the newly developed respiratory disease that is caused by a novel coronavirus which was first testified in Wuhan, China in December 2019. (Hussain et al., 2020) The common clinical manifestations of this highly infectious disease, fever, dry cough, tiredness and less common symptoms are aches, pain, sore throat, diarrhea, conjunctivitis, headache, loss of taste or smell, a rash on skin, or discoloration of fingers or toes. The most Serious symptoms which can put the patient in life threatening condition are difficulty breathing or shortness of breath, chest pain or pressure, loss of speech or movement (WHO, 2020) The health care workers' adherence to the recommended measures taken to prevent trans mission are inevitable to minimize the increasing number of COVID-19 cases. This can be achieved by enhancing knowledge, positive attitudes, and infection control practices of the frontline workers (Ejeh et al., 2020). Objective: The objective of the present study was to access the knowledge, attitude, and practices of healthcare professionals on covid-19 and risk assessment to prevent the epidemic spread at tertiary care hospitals Lahore. Methodology: A cross sectional study design was selected. Information was collected about demographic characteristics and knowledge, attitude and practice. SPSS were used for data collection. Results: A sample of 200 healthcare workers was collected from four different tertiary care hospitals. A descriptive statistic was applied on data. In descriptive analysis frequency tables and graph were used to represent research findings of total sampled population majority respondents were females (98.5%) between the age of 20-25 years (39%). Most of the respondents were unmarried (62%), (94%) staff nurses. Conclusion: This study concluded that Health care professionals are the frontline workers dealing with the covid-19. In this study nurses had a good knowledge, positive attitude and practice regarding covid -19. In contrast, training programs can improve the understanding of risk and prevention strategies regarding covid 19.