The sponge Suberites carnosuswas collected during low tides from West Coast of Mumbai. Crude extract was obtained by taking 10 gram of sponge samples in10 ml of methanol. In the present investigation we found the crude protein contents in Suberites carnosus as 0.096 mg/mL. The Neuromodulatory Na (+)-K+ ATPase activity and AChE on Sprague dawley rat brain and chicken brain extract may contribute to the pathogenesis of metabolic complications of the central nervous system, and that the undetectable enzyme activity in chicken brain convulsing chicken brain may result from considerable damage or necrosis of brain tissue during seizures. In A Ch E our study is evident that both the sponge extract showed enzyme inhibitor activity at certain concentrations. In hemolytic activity showed potent toxin which is responsible for hemagglutination. Hemagglutination activity is generated by the presence of protein and the protein found in sponges which usually show hemmaglutination activity that might be because of presence of lectin which showed hemolytic activity. In CAM study showed that methanolic extract has strong antiangiogenic activity. The protein bands showed lectins have variety of effects on cells, such as agglutination, mitogenic stimulation, redistribution of cell surface components, modifying the activity of membrane enzymes, inhibition of bacterial and fungal growth, cell aggregation, toxicity, immunomodulation.