Aim: To systematically examine the published findings on the clinical effectiveness of periodontal therapy on anemic status of patients with chronic periodontitis. Method: A systematic search was conducted using MEDLINE, Cochrane Central Register of Controlled Trials, Google Scholar, Google, Clinical trials registry and manual search using DPU Vidyapeeth library resources were searched up to 31st October 2019 to identify appropriate studies. All cross reference lists of the chosen studies were also screened. Two reviewers assessed the eligibility of studies. Results: The electronic and manual search identified a total of 138 articles. A final screen consisted of 21 articles out of which 16 articles were selected for full-text assessment. Finally, 5 articles were selected for detailed evaluation for the systematic review which evaluated the efficacy of effect of periodontal therapy on anemic patients with chronic periodontitis. Conclusions: Chronic periodontitis may cause to anemia and provides evidence that non-surgical periodontal therapy can improve the anemic status of patients with chronic periodontitis.